Weeks Bay Reserve encompasses more than 6,000 acres of tidal and forested wetlands within the greater Mobile Bay estuarine system along the northern Gulf of Mexico. Weeks Bay is a small estuary fringed with a variety of wetland habitats receiving freshwater from the Fish and Magnolia Rivers. Located along the eastern shore of Mobile Bay between the major metropolitan areas of Mobile, AL and Pensacola, FL, the Reserve's land (1,645 acres) and water (4,880 acres) habitats support numerous rare and endangered species including the brown pelican, eastern indigo snake and the Alabama red-bellied turtle. Significant efforts have been made to restore a regionally significant habitat at the Reserve. Fire dependent, pitcher plant bogs contain a myriad of rare species and are easily accessible on the Reserve's self-guiding nature trails.

Weeks Bay Reserve is located near Mobile Bay's eastern shore about 40 miles southeast of Mobile, Ala. The Interpretive Center and main offices are located on U.S. 98, about 12 miles southeast of Fairhope.