Tewaukon National Wildlife Refuge (NWR) is located in southeastern North Dakota along the western edge of the northern tallgrass prairie. The Wild Rice River flows through the Refuge and then into Lake Tewaukon. Established in 1945, the 8,363-acre Refuge is located in the Prairie Pothole Region, one of the most biologically productive areas on earth.

Tewaukon NWR is located about 5 miles south of Cayuga, North Dakota. From North Dakota Highway 11 turn south on Sargent County Road 12. The visitor center is on the east side of the road.