Seney National Wildlife Refuge has been shaped by forces of nature and humans and reflects the evolving face of preservation, conservation, and restoration. Its creation story tells of features left by the glacier in the surrounding area known as the Great Manistique Swamp, and of the land's recovery from the human impact of logging and farming. Here the sun reflects off life-giving water that covers over half of the refuge, and regal pairs of trumpeter swans (part of a successful reintroduction project) glide across the refuge pools. The haunting cry of the common loon is often heard drifting across the waters of Seney Refuge, and bald eagles are often spotted along the seven-mile auto tour route. Seney Refuge protects 95,212 acres and was established in 1935 to provide habitat for migratory birds and resident wildlife. Currently, it is home to over 200 species of birds and a variety of mammals, amphibians, reptiles, fish, and invertebrates. Its diverse wetland and upland habitats support a wide variety of wildlife, and Seney's programs, events, tours, facilities and opportunities make it "A Great Place to Watch Wildlife."

The refuge headquarters and visitor center are located in the east-central Upper Peninsula of Michigan on highway M-77, two miles north of Germfask and six miles south of Seney, Michigan.