Enjoy majestic views of the Ohio River along the entirety of this scenic route. Native Americans and early European settlers used the Ohio heavily. It marked the boundary between the North and South during the slavery era and was the gate to freedom for many.

Getting to the Byway:

###From Cincinnati, OH###

• The byway runs along the river adjacent to US-50.

###From Columbus, OH###

• Take US-23 south to US-52 in Portsmouth where you enter the byway.

###Alternate Route from Columbus, OH###

• Take I-70 East to Bridgeport, OH where you enter the byway.

###Alternate Route from Columbus, OH###

• Take US 33 southeast to Pomeroy, OH where you enter the byway.

###From Cleveland, OH###

• Take I-77 south to Marietta, OH where you enter the byway.

###From Charleston, WV###

• Take I-64 West to Huntington, WV and cross the Ohio River at any Ohio River bridge to enter the byway.

###Alternate Route from Charleston, WV###

• Take I-77 north to Marietta, OH where you enter the byway.

###From Louisville, KY###

• Take I-71 north to Cincinnati, OH where you enter the byway.

### From Pittsburgh, PA###

• Take I-79 south to 1-70 in Washington, PA to Bridgeport, OH where you enter the byway.

Navigating the Byway:
The Ohio River Scenic Byway through Ohio runs from the Indiana state border on US 52 along the Ohio River to the Pennsylvania state border. * The byway begins near Cincinnati, Ohio on Highway 50. * In Cincinnati take Highway 52 southeast. * Follow Highway 52 as it meanders across the state. Near Proctorville Highway 52 becomes State Route 7. * After Pomeroy take State Route 124 southeast towards Minersville. * Take State Route 338 south at Racine and follow it until it reunites with SR 124. * Follow SR 124 to Little Hocking where it reunites with Highway 7. * The road enters Wayne National Forest about 7 miles after Marietta and exits the forest after 27 miles. * Follow Highway 7 to the end of the byway, at East Liverpool.