The North Platte River is the only floatable waterway in central Wyoming and has become the destination fishery for the state. Scenic and recreational values of the North Platte River are derived from a combination of environmental factors and management practices. The river is highly valued as a class 1 fishery. The Wyoming Game and Fish Department has rated it as a blue ribbon fishery. Game fish species include rainbow, brown and cutthroat trout. The most common recreation activities are fishing, floating, waterfowl hunting, and observing wildlife. There are also opportunities for picnicking and camping. This river has become a vital part of the social and economic values of central Wyoming.

There are various access points along the river.