North Platte National Wildlife Refuge (NWR) is located 8 miles northeast of Scottsbluff in the Nebraska panhandle. Superimposed over Bureau of Reclamation irrigation projects, the four Refuge units consist of Winters Creek, Lake Alice, portions of Lake Minatare, and Stateline Island (located south of Henry, Nebraska).

Lake Minatare and Winters Creek: From US Highway 26, travel north on Sugar Factory Road approximately 5 miles to Lake Minatare Road. Turn east and travel approximately 6 miles to Stonegate Road. Turn north on Stonegate, The entrance to Lake Minatare is approximately 2 miles; the Winters Creek entrance is just beyond on the opposite side of the road. Lake Alice: From US Highway 26, travel north on Sugar Factory Road to County Road C (approximately 7 miles). Turn east on County Road C approximately 2 miles to the Lake Alice entrance. Stateline Island: From U.S. Highway 26 at Henry, Nebraska, travel south on Holloway Road approximately 1 mile to the entrance and parking area.