Moosehorn is one of the northern most national wildlife refuges in the Atlantic Flyway, a migratory route that follows the eastern coast of North America. The refuge provides important feeding and nesting habitat for many bird species, including waterfowl. Wading birds, shorebirds, upland game birds, songbirds, and birds of prey. The refuge consists of two divisions. The Baring Division covers 20,016 acres and is located off U.S. Route 1, southwest of Calais. The 8,735 acre Edmunds Division is between Dennysville and Whiting on U.S. Route 1 and borders the tidal waters of Cobscook Bay. Each division contains a National Wilderness Area, thousands of acres managed to preserve their wild character for future generation.

Moosehorn National Wildlife Refuge is located off Route 1 southwest of Calais, ME. It can be reached by taking Route 1 North from coastal Maine, Route 1 South from northern Maine, or Route 9 east from the Bangor area. From Route 1, follow signs to the Refuge Headquarters about 3 miles south on the Charlotte Road. The office is open Monday - Friday, from 8 a.m. - 4 p.m., except holidays. An information booth provides after - hours visitors with brochures and maps.