Meredosia National Wildlife Refuge is 3,582 acres and is located in the upper end of the Alton Navigation Pool in an area that was historically known for its ability to sustain fish and wildlife. The refuge was established to provide an inviolate sanctuary for wildlife, primarily for waterfowl and other migratory birds. Land management programs are designed and administered to promote migratory bird, fish, and resident wildlife habitat in the Illinois River basin, while providing for public recreation opportunities.

The Refuge is managed under the Illinois River National Wildlife and Fish Refuges Complex. Emiquon and Chautauqua National Wildlife Refuges are also managed under this refuge complex.

From Beardstown: Follow Route 67 south from Beardstown approximately 10 miles to Highway 104. Turn west onto Highway 104. Follow approximately 5 miles. Turn north onto Putnam Street. Follow Putnam to Gaskill. Turn east and then north onto Beach Road. Follow Beach Road 1/2 mile to refuge.

From Jacksonville: Follow Route 67 north approximately 25 miles to Highway 104. Turn west onto Highway 104 approximately 5 miles. Turn north onto Putnam Street. Follow Putnam to Gaskill. Turn east and then north onto Beach Road. Follow Beach Road 1/2 mile to refuge.