This byway offers an ever-changing panorama as it winds along the Mississippi River. Limestone bluffs provide stunning views in the National Register Districts of Clarksville and Louisiana, home of artist colonies and antiques galore. History buffs, art lovers, and antique hounds find a haven here in a spectacular riverfront setting.

Getting to the Byway:

St. Louis, MO

• Take I-70 west to St. Peters.
• Get on MO-79 and go north to Clarksville where the byway begins.

Navigating the Byway:
The byway begins on MO 79 at the Ralls-Pike county line 15 miles south of Hannibal. ##Ralls-Pike County Line to Clarksville (29 miles) * From the beginning of the byway, follow MO 79 to the town of Louisiana. * Once in Louisiana, turn east (left) onto US 54, then south (right) onto MO 79/ 3rd St. * Continue on MO 79 into Clarksville, where the Missouri section of the Great River Road ends at the intersection of MO 79 and Howard St.