Lake Alice National Wildlife Refuge (NWR) is located in Ramsey and Towner Counties near the former town of Church's Ferry, North Dakota. These watersheds cover 1,000 square miles of land and provide ample water to Lake Alice NWR. All of these watercourses are considered intermittent, but they are prone to flooding in spring and during heavy rainstorms.

Lake Alice NWR is administered from the Devils Lake Wetland Management District Office located in Devils Lake, North Dakota, and is located about 15 miles northwest of Devils Lake. From the intersection of U.S. Highway 2 and North Dakota Highway 20 in Devils Lake, go 17 miles north to Ramsey County Road 10. On Ramsey County Road 10, go 7 miles west, 1 mile north, and 2 miles west to reach the north side of the Refuge. To reach the south side of the Refuge, from the intersection of U.S. Highway 2 and North Dakota Highway 20 in Devils Lake, go 12 miles northwest to the town of Penn. Go north 7 miles on the township road.