Iroquois National Wildlife Refuge lies midway between Buffalo and Rochester, NY, within the Atlantic Flyway. The relatively flat terrain encompasses 10,828 acres of habitat. Freshwater marshes and hardwood swamps border or are fed by Oak Orchard Creek which meanders east to west before leaving the refuge to empty into Lake Ontario 20 miles away. Forests, meadows and fields slope up gently from the wetland's edge. When planning for your trip to the refuge you should contact the refuge headquarters to gather pertinent information on the refuge and surrounding area.

From the New York State Thruway (I-90) take exit 48-A (Pembroke/Medina). Go north on Route 77 for approximately 8 miles. At the 4-way stop light in Alabama Center continue straight for one more mile to Casey Road. Turn left on Casey Rd. The Headquarters Building is one mile west.