Featherstone NWR is located about 22 miles south of Washington D.C. at the confluence of Neabsco Creek and the Potomac River. The refuge is managed by staff of the Potomac River NWR Complex. Composed of wetlands and woodlands, the refuge is a narrow strip along the shore of the Potomac River and mouth of Neabsco Creek with a railroad right of way bordering the western edge. The refuge provides habitat for Neotropical migrants, waterfowl, ospreys, and historically bald eagles. There is no public access site for the refuge and it remains closed to public use. Refuge staff are working with Prince William County to provide an access site and the refuge has been identified as providing a possible route for the Potomac Heritage Natural Scenic Trail.

The refuge is closed to the public.