The Chassahowitzka National Wildlife Refuge, established in 1941, is comprised of over 31,000 acres of saltwater bays, estuaries and brackish marshes at the mouth of the Chassahowitzka River. The refuge, located approximately 65 miles north of St. Petersburg, FL, was established primarily to protect waterfowl habitat and is home to over 250 species of birds, over 50 species of retiles and amphibians, and at least 25 different species of mammals, including the endangered West Indian Manatee.

The Chassahowitzka NWR is located approximately 65 miles north of St. Petersburg, FL. A boat ramp, maintained by the Citrus County, provides a launching point for boats on the Chassahowitzka River for a small fee. To get there take U.S. Hwy. 19 north from St. Petersburg (or south from Perry) to State Road 480. Proceed west on State Road 480, the Chasshowitzka Boat Ramp is located at the end of this road. The refuge is located approximately three miles down river from this boat ramp.

Rental boats and tour guides are available in nearby towns of Chassahowitzka and Homosassa. Contact the Chamber of Commerce in Homosassa for listings. Make reservations in advance.