Cache River National Wildlife Refuge (NWR) was established in 1986 to protect significant wetland habitats and provide feeding and resting areas for migrating waterfowl. As one of the few remaining areas in the Lower Mississippi River Valley not drastically altered by channelization and drainage, the Cache River basin contains a variety of wetland communities including some of the most intact and least disturbed bottomland hardwood forests in the Mississippi Valley region. These unique and valuable wetlands have been protected by the RAMSAR Convention as "Wetlands of International Importance".

At present the refuge currently encompasses over 56,000 acres located in numerous non-contiguous tracts in Jackson, Woodruff, Monroe and Prairie counties in east central Arkansas. The boundary of this refuge changes frequently as land acquisition continues along the Cache River, White River and Bayou Deview.

Cache River NWR Headquarters is located 16 miles south of Augusta, Arkansas on Highway 33. From US Highway 64, turn south on Highway 33. Follow Highway 33 approximately 16 miles. The headquarters is on the left side of the road.